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. 2021 Oct 11;13(11):e13659. doi: 10.15252/emmm.202013659

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© 2021 The Authors. Published under the terms of the CC BY 4.0 license

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Figure EV1 — The scheme displays our overall experimental approach and the various filtering steps to identify circulating microRNAs that informs about the cognitive reserve and would allow the early detection of patients at risk for developing cognitive decline. We hypothesized that a promising approach would be to first identify circulating microRNAs that correlate with memory performance in young and healthy humans. Based on the function of such microRNAs, we then thought to employ model systems to further refine these data and develop a microRNA signature that could then be analyzed at the functional level and be eventually tested in patients and disease models. We also planned to test the potential of such a microRNA signature for RNA therapeutics with the aim to ameliorate cognitive decline.