Table 1.

Serum biochemistry of Sema7a ^R145W mutant mice (8‐week‐old).

	Wild type (n = 6)	Heterozygote (n = 10)	Homozygote (n = 12)
Gender (male/female)	2/4	6/4	7/5
Serum ALT (IU/l)	21.00 ± 2.69	27.14 ± 8.24	75.23 ± 99.65 a , b
Serum AST (IU/l)	83.26 ± 19.91	97.81 ± 34.87	244.40 ± 185.40 a , b
Serum ALP (IU/l)	98.80 ± 57.10	86.45 ± 36.04	93.91 ± 82.04
Serum TBA (μmol/l)	1.86 ± 0.51	2.28 ± 1.05	90.03 ± 121.39 a , b
Serum TBIL (μmol/l)	0.98 ± 1.15	3.65 ± 7.64	7.28 ± 5.18 a , b
Serum DBIL (μmol/l)	0.39 ± 0.61	2.91 ± 6.59	4.63 ± 4.38 a

Values are mean ± SD.

ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; TBA, total bile acids; TBIL, total bilirubin; DBIL, direct bilirubin.

^a P < 0.05 versus the WT mice.

^b P < 0.05 versus the heterozygous mutant mice. The data were analyzed by the independent‐samples Student's t‐test or the Mann–Whitney U‐test when applicable.