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. 2021 Nov 2;13(11):e14146. doi: 10.15252/emmm.202114146

Figure 4. Clearance of senescent cells prevents glomerulosclerosis, podocyte loss, and PAI‐1 overexpression during aging.

Figure 4

  1. Morphology (PAS staining, upper panels) and quantification of glomerular lesions (lower panel) of kidneys from 28‐month‐old p16 INK‐ATTAC mice treated with either vehicle (AP−) or AP20187 (AP+). Original magnification ×400. Scale bar = 20 μm. n = 5.
  2. WT1 immunostaining (upper panels) and quantification of WT1‐positive glomerular cells (lower panel) in 28‐month‐old p16 INK‐ATTAC mice treated with either vehicle (AP−) or AP20187 (AP+). Original magnification ×400. Scale bar = 20 μm. n = 5.
  3. PAI‐1 immunostaining (upper panels) and quantification of PAI‐1‐positive glomeruli (lower panel) in 28‐month‐old p16 INK‐ATTAC mice treated with either vehicle (AP−) or AP20187 (AP+). Original magnification ×400. Scale bar = 20 μm. n = 5.

Data information: Data are means ± SEM. Statistical analysis: Student's t‐test: AP+ vs AP− mice.