Table 2.
Clinical data in PAI‐1‐positive and PAI‐1‐negative kidney recipients at time of transplantation.
|
PAI‐1‐negative glomeruli (n = 17) |
PAI‐1‐positive glomeruli (n = 18) |
P | |
|---|---|---|---|
| Recipient age, years | 70 (65–73) | 69 (67–72) | 0.92 |
| Donor age, years | 82 (81–84) | 82 (80–83) | 0.36 |
| Males, n (%) | 7 (41%) | 11 (61%) | 0.32 |
| HLA donor‐specific antibody, n | 0 | 0 | 1.00 |
| Cold ischemia time, min | 1,101 (964–1,440) | 1,120 (810–1,620) | 0.65 |
| Donor eGFR (ml/min/1.73 m2) | 82 (71–120) | 82 (72–87) | 0.66 |
| Delayed graft function, n (%) | 3 (18%) | 3 (17%) | 1.00 |
| Dual transplantation, n (%) | 11 (65%) | 14 (78%) | 0.53 |
| Immunosuppressive treatment | |||
| Tacrolimus, n (%) | 13 (77%) | 13 (72%) | 1.00 |
| Cyclosporine, n (%) | 4 (24%) | 5 (28%) | 1.00 |
| Steroids, n (%) | 17 (100%) | 18 (100%) | 1.00 |
| Mycophenolic acid, n (%) | 17 (100%) | 18 (100%) | 1.00 |
| Morphological data at M0 | |||
| Glomerulosclerosis score, AU | 0.9 (0.3–1) | 0.5 (0.2–0.7) | 0.14 |
| Severe arteriosclerosis, n (%) | 7 (41%) | 12 (66.7%) | 0.18 |
| Severe interstitial fibrosis, n (%) | 7 (41%) | 12 (66.7%) | 0.29 |
Negative and positive glomerular PAI‐1 staining was performed on donor kidney biopsies at time of transplantation. AU, arbitrary unit; eGFR, estimated glomerular filtration rate; M0, time of transplantation; Tx, transplantation. Severe arteriosclerosis and severe interstitial fibrosis were defined as CV3 and IF/TA3 according to the Banff classification. Data are expressed as median with interquartile (IQ25–IQ75) except if indicated. Fisher's exact test and Mann–Whitney U‐test were used for the comparison of qualitative and continuous variables, respectively.