Table 3.
Clinical data in PAI‐1‐positive and PAI‐1‐negative kidney recipients 12 months after transplantation.
|
PAI‐1‐negative glomeruli (n = 17) |
PAI‐1‐positive glomeruli (n = 18) |
P | |
|---|---|---|---|
| Post‐Tx diabetes, n (%) | 5 (29%) | 6 (33%) | 1.00 |
| BMI, kg/m2 | 24 (20–25) | 24 (22–26) | 0.40 |
| Acute rejection, n (%) | 3 (18%) | 3 (17%) | 1.00 |
| BK viremia, n (%) | 1 (6%) | 1 (6%) | 1.00 |
| Plasma creatinine, μmol/l | 109 (90–130) | 155 (129–182) | < 0.001 |
| eGFR, ml/min/1.73 m2 | 45.6 (40–56) | 29.1 (25–37) | < 0.001 |
| Morphological data | |||
| Glomerulosclerosis score, AU | 0.55 (0.31–0.82) | 1.00 (0.55–1.43) | < 0.05 |
| Severe arteriosclerosis, n (%) | 11 (65%) | 9 (50%) | 0.50 |
| Severe interstitial fibrosis, n (%) | 10 (59%) | 8 (44%) | 0.51 |
PAI‐1 staining to define positive and negative glomeruli was performed on donor kidney biopsies at time of transplantation. AU, arbitrary unit; BMI, body mass index; eGFR, estimated glomerular filtration rate; Tx, transplantation. Severe arteriosclerosis and severe interstitial fibrosis were defined as CV3 and IF/TA3 according to the Banff classification. Data are expressed as median with interquartile (IQ25–IQ75) except if indicated. Fisher's exact test and Mann–Whitney U‐test were used for the comparison of qualitative and continuous variables, respectively.