TABLE 1.
Description of the AMU data, including data for prophylactic AMU analysis (No. weeks with prophylactic AMU and number of weeks without AMU) and therapeutic AMU analysis (No. weeks before and after therapeutic AMU). The data are stratified by antimicrobial class (by row). The ranges reflect the variability resulting from different combinations of the tuning parameters of the categorization algorithm
| Classes | raw AMU data | Data for prophylactic effect analysis | Data for therapeutic effect analysis | ||||
|---|---|---|---|---|---|---|---|
| No. flocks N = 349 (%) | No. weeks N = 5,566 (%) | No. weeks with prophylactic AMU (%) | No. weeks with non‐AMU (%) | No. disease episodes | No. weeks before therapeutic AMU | No. weeks after therapeutic AMU | |
| Aminoglycosides | 158 (45.3) | 367 (6.6) | 125–250 (34.1–68.1) | 2,841–4,554 (54.6–87.6) | 44–100 | 53–396 | 0–103 |
| Amphenicols | 66 (18.9) | 100 (1.8) | 51–80 (51–80) | 3,236–4,984 (59.2–91.2) | 13–30 | 44–541 | 0–35 |
| Cephalosporins | 7 (2.0) | 9 (0.2) | 2–8 (22.2–88.9) | 3,412–5,139 (61.4–92.5) | 0–1 | 298–623 | 0–4 |
| Diaminopyrimidines | 56 (16.0) | 106 (1.9) | 33–74 (31.1–69.8) | 3,258–4,978 (59.7–91.2) | 18–34 | 191–568 | 0–29 |
| Lincosamides | 24 (6.9) | 33 (0.6) | 15–30 (45.5–90.9) | 3,367–5,093 (60.9–92) | 4–9 | 197–607 | 0–9 |
| Macrolides | 137 (39.3) | 310 (5.6) | 117–220 (37.7–71) | 2,909–4,638 (55.3–88.2) | 22–68 | 45–478 | 2–53 |
| Penicillins | 113 (32.4) | 208 (3.7) | 95–160 (45.7–76.9) | 3,023–4,791 (56.4–89.4) | 34–61 | 145–498 | 0–57 |
| Pleuromutilins | 1 (0.3) | 1 (0.0) | 1–1 (100–100) | 3,419–5,154 (61.4–92.6) | 0–0 | 0–0 | 0–0 |
| Polypeptides | 252 (72.2) | 605 (10.9) | 261–407 (43.1–67.3) | 2,249–4,158 (45.3–83.8) | 63–133 | 37–340 | 0–109 |
| Quinolones | 98 (28.1) | 168 (3.0) | 74–129 (44–76.8) | 3,113–4,870 (57.7–90.2) | 20–39 | 42–538 | 2–50 |
| Sulphonamides | 83 (23.8) | 148 (2.7) | 65–109 (43.9–73.6) | 3,138–4,906 (57.9–90.6) | 22–50 | 46–527 | 1–52 |
| Tetracyclines | 258 (73.9) | 628 (11.3) | 266–432 (42.4–68.8) | 2,223–4,117 (45–83.4) | 57–127 | 43–339 | 0–136 |
| Methenamines | 26 (7.4) | 36 (0.6) | 15–31 (41.7–86.1) | 3,356–5,091 (60.7–92.1) | 7–16 | 201–619 | 0–1 |
| Any class | 296 (84.8) | 1,266 (22.7) | 353–686 (27.9–54.2) | 1,564–3,251 (36.4–75.6) | 144–310 | 21–164 | 1–153 |
Antimicrobial agents within each class: Aminoglycosides: neomycin, gentamicin, streptomycin, spectinomycin, apramycin, josamycin. Amphenicols: florfenicol, thiamphenicol, chloramphenicol. Cephalosporins: cefadroxil, cefotaxime, cephalexin, ceftiofur. Diaminopyrimidines: trimethoprim. Lincosamides: lincomycin. Macrolides: tylosin, tilmicosin, erythromycin, spiramycin, kitasamycin. Penicillins: amoxicillin, ampicillin. Pleuromutilins: tiamulin. Polypeptides: colistin, enramycin. Quinolones: enrofloxacin, flumequine, norfloxacin. Sulphonamides: sulphachloropyridazine, sulphadiazine, sulphadimethoxine, sulphadimidine, sulphaguanidine, sulphamethazine, sulphamethoxazole, sulphamethoxypyridazine, sulphamethoxazole, sulphathiazole. Tetracyclines: oxytetracycline, doxycycline, tetracycline. Methenamines: methenamine.