Table 2.

Risk of femoral fracture based on patient, tumor, and treatment variables.

	Crude risk	Cumulative risk over 5 years	95% CI	P value
Gender
Female	5/46	11.4%	4.4–29.8%	0.02
Male	2/99	2.3%	0.6–9.0%
Age
Age < 60 years	1/82	1.2%	0.2–8.7	0.02
Age ≥ 60 years	6/63	10.3%	4.4–24.2%
Compartment
Anterior	6/62	9.7%	4.1–22.8%	0.02
Other	1/83	1.4%	0.2–10.1%
Tumor size
< 10 cm	1/61	0%	n/a	0.07
≥ 10 cm	6/84	9.2%	4.2–20.2%
Periosteal stripping
Present	3/28	12.6%	4.2–37.5%	0.06
Absent	4/117	3.3%	1.1–10.1%
Dose
≤ 60 Gy	1/35	3.3%	0.5–22.9%	0.53
> 60 Gy	6/110	5.4%	2.2–12.8%
Chemotherapy
No chemotherapy	5/94	5.3%	2.0–13.9%	0.82
Chemotherapy	2/51	4.0%	1–15.6%
IMRT constraints utilized
No (2004–2010)	6/84	7.4%	3.1–17.6%	0.11
Yes (2011–2016)	1/61	1.8%	0.3–12.2%