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Schematic representation of the relation between FH+ and Alcohol Use Frequency at age 16 years with (b) and without (a) controlling for EXT 11-16 years. The indirect effect from FH+ to alcohol use frequency through EXT 11-16 (reflected by the difference between path c [a] and c’ [b]) was significant (ab = 0.109; SE = 0.053, CI, 0.024 to 0.228). The same associations were seen for alcohol use onset and cannabis use frequency at age 16 years. See details in the Results section.
