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Age at onset of symptoms and treatment effect based on a review of the literature. (a) Age of symptoms onset of each group. The data were analyzed by one-way ANOVA followed by Bonferroni post hoc test. ***p < 0.001. (b-e) The relationship between age of symptoms onset and treatment effect in each group. (A higher resolution / colour version of this figure is available in the electronic copy of the article).
