Table 2. Name, gender and age of patients experienced ADRs with use of vortioxetine in clinical trials.

Adverse Drug Reactions (ADRs)	Number of Patients	Age	Gender	Dose	Phase	References
Headache, nausea, sedation, upper abdominal pain, fatigue, vomiting, decreased appetite, and irritability	48	7-17	Male and female	5,10,15 or 20 mg/day	Phase III	[16]
Sexual dysfunction, nausea, depression, anxiety, insomnia, vomiting, nausea, headache, dizziness, pruritus, fatigue, anxiety	711	18–55	Male and female	10-20mg/day	Phase III	[17]
Nausea	151	18-65	Male and female	10-20 mg/day	Phase III	[18]
Nausea, headache, dizziness, somolence	493	18-75	Male and female	10-20 mg/day	Phase III	[19]
Nausea, constipation, dry mouth, dizziness, and insomnia	600	20-64	Male and female	5, 10, or 20 mg/day	Phase III	[20]