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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: J Hepatol. 2021 Jan 27;74(6):1429–1441. doi: 10.1016/j.jhep.2021.01.028

Figure 4. Stard1 ΔHep mice are less sensitive to DEN plus HFHC induced HCC.

Figure 4.

A-B) Macroscopic images of livers from Stard1f/f (N=9) and Stard1ΔHep mice (N=9) treated with DEN and fed HFHC diet for 24 weeks, with quantification of tumor multiplicity and maximal area.

C-D) Serum and mRNA expression levels of Afp from Stard1f/f (N=9) and Stard1ΔHep mice (N=9) treated with DEN and fed HFHC.

E) Immunohistochemical expression of Afp and Yap of consecutive liver sections from Stard1f/f and Stard1 ΔHep mice.

F-G) mRNA levels tumor markers and inflammation genes of whole liver tissue from Stard1f/f and Stard1ΔHep mice.

H) mRNA levels of ER stress markers of whole liver tissue from Stard1f/f (N=6) and Stard1ΔHep mice (N=6).

I) Western blot of ER stress markers as in H).

All values are mean ± SEM. *p<0.05, denote statistically significant differences respect to MUP-uPAStard1f/f or Stard1f/f mice in Student’s t test.