Table 1.
Particle Characteristics for NEXThaler DPI (BDP/FF), Ellipta DPI (FluF/Vil), and Turbohaler DPI (Bud/FF)
| Devicea | Active pharmaceutical ingredient | Mass median aerodynamic diameter (μm) | Geometric standard deviation | DD (μg) | Fine particle fraction (% of DD) | Drug release time (second) |
|---|---|---|---|---|---|---|
| 60 L/min flow rate | ||||||
| NEXThaler DPI 100 + 6 μg |
BDP | 1.3 | 2.6 | 81.9 | 56.8 | 0.099 |
| FF | 1.5 | 1.8 | 5.0 | 58.7 | ||
| Ellipta DPI 92 + 22 μg |
FluF | 3.8 | 2.1 | 91.6 | 23.8 | 0.124 |
| Vil | 2.1 | 2.1 | 22.5 | 45.3 | ||
| Turbohaler DPI 200 + 6 μg |
Bud | 2.1 | 1.8 | 163.5 | 62.2 | 0.137 |
| FF | 2.1 | 1.9 | 4.6 | 62.8 | ||
| 40 L/min flow rate | ||||||
| NEXThaler DPI 100 + 6 μg |
BDP | 1.2 | 2.4 | 81.9 | 59.7 | 0.124 |
| FF | 1.6 | 1.9 | 5.0 | 58.6 | ||
| Ellipta DPI 92 + 22 μg |
FluF | 4.1 | 2.1 | 90.7 | 23.7 | 0.131 |
| Vil | 2.2 | 2.3 | 22.1 | 42.3 | ||
| Turbohaler DPI 200 + 6 μg |
Bud | 2.8 | 1.8 | 138.4 | 48.1 | 0.167 |
| FF | 2.7 | 1.9 | 3.9 | 48.4 | ||
| 30 L/min flow rate | ||||||
| NEXThaler DPI 100 + 6 μg |
BDP | 1.5 | 2.6 | 84.4 | 57.3 | 0.171 |
| FF | 2.3 | 2.0 | 4.9 | 54.6 | ||
| Turbohaler DPI 200 + 6 μg |
Bud | 3.0 | 1.9 | 125.8 | 29.5 | 0.407 |
| FF | 2.9 | 1.8 | 3.5 | 29.8 | ||
a
Doses shown are for ICS and LABA, respectively. Presented results are mean of two replicate measurements performed on a single unit for each device.
BDP, beclomethasone dipropionate; Bud, budesonide; DD, delivered dose; DPI, dry powder inhaler; FF, formoterol fumarate; FluF, fluticasone furoate; ICS, inhaled corticosteroid; LABA, long-acting beta2-agonist; Vil, vilanterol trifenatate.