TABLE 2.
FMRP mRNAs interactors.
| Gene | Protein | Function | OMIM ID | References |
|---|---|---|---|---|
| FMR1 | FMRP | RNA binding protein | 309550 | Santoro et al. (2011), Schaeffer et al. (2001) |
| APP | Amyloid precursor protein | Transmembrane protein/cell signaling | 104760 | Sokol et al. (2011) |
| MMP9 | Matrix metalloproteinase 9 | Enzyme/collagenase/gelatinase | 120361 | Janusz et al. (2013) |
| MAP1B | Microtubule-associated protein 1B | Microtubule-associated protein | 157129 | Menon et al. (2008), Dictenberg et al. (2008) |
| CAMK2A | Calcium/calmodulin-dependent protein kinase type II alpha chain | Protein kinase | 114078 | Davis et al. (2017) |
| DLG4 | Post-synaptic density protein 95 (PSD-95) | cytoskeleton/scaffolding | 602887 | Santoro et al. (2012) |
| KCNC1 | Voltage-gated potassium channel subunit Kv3.1 | Transmembrane protein/ion channel | 176258 | Strumbos et al. (2010) |
| KCND2 | Voltage-gated potassium channel subunit Kv4.2 | Transmembrane protein/ion channel | 605410 | Davis et al. (2017) |
| ARC | Actvity-regulated cytoskeleteon-associated protein | Actin-binding protein | 612461 | Darnell et al. (2001) |
| EEF2 | Eukaryotic translation elongation factor 2 | GTP-binding protein | 130610 | Park et al. (2008) |
| SAPAP4 | SAP 90/PSD95 associated protein | RNA-binding protein | 616191 | Davis et al. (2017), Brown et al. (2001), Miyashiro et al. (2003) |
| BC1 | Brain Cytoplasmic RNA 1 | ncRNA | 606089 | Zalfa et al. (2005), Iacoangeli et al. (2008) |
| GBRB | Gamma-aminobutyric acid receptor subunit BETA | Transmembrane protein receptor | 137163 | Wolfe et al. (2016) |
| MBP | Myelin basic protein | Membrane protein | 159430 | Giampetruzzi et al. 2013 |
| SOD 1 | Superoxide dismutase 1 | Enzyme | 147450 | Bechara et al. (2009) |
| RGS5 | Regulator of G protein signaling 5 | GTPase activator | 603276 | Brown et al. (2001), Filipello et al. (2018) |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 | GTP-binding protein | 602048 | Billuart et al. (2003) |
| RhoA | RHOA | GTP-binding protein | 165390 | Tsai et al. (2010) |
| ARHGEF12 | Rho guanine nucleotide exchange factor 12 | Cytoplasmic/membrane protein/G protein- coupled receptor binding | 604763 | Heulens et al. (2011) |
| SPEN | Msx2-interacting protein | DNA/RNA binding | 613484 | Brown et al. (2001) |
| NR3C1 | Glucocorticoid receptor, group C, member 1 | Membrane protein/adhesion molecule | 138040 | Markham et al. (2006) |
| CTNNB1 | Catenin β-1 | Membrane protein and transcriptional factor | 116806 | Ehyai et al. (2018) |
| PCLO | Piccolo | Protein transporter | 604918 | Pasciuto and Bagni (2014) |
| EEF2 | Eukaryotic translation elongation factor 2 | GTP-binding protein | 130610 | Park et al. (2008) |
| APC | Adenomatous polyposis coli | Microtubule-binding protein/kinase regulator | 176915 | Huang et al. (2015) |
| ALDOA | Fructose-bisphosphate aldolase A | Enzyme/scaffolding | 103850 | Pasciuto and Bagni (2014) |
| AP2B1 | AP-2 complex subunit β-1 | Protein transporter | 601025 | Van Driesche (2019) |
| FUS | RNA-binding protein FUS | DNA/RNA-binding protein | 137070 | He et al. (2017) |
| VDAC1 | Voltage-dependent anion-selective channel protein 1 | Transmembrane protein/Ion channe | 604492 | Chen et al. (2003) |
| HNRNP A2B1 | Heterogeneous nuclear RiboNucleoProtein A2/B1 | RNA-binding protein | 600124 | Sofola et al. (2007) |
| PKP4 | Plakophilin 4 | Adhesion molecule | 604276 | Fischer-Kešo et al. (2014) |
| NLGN2 | Neuroligin 2 | Transmembrane protein/receptor | 606479 | Chmielewska et al. (2019) |
| DAG1 | Dystrophin-associated glycoprotein 1 | Enzyme | 613818 | Pasciuto et al. (2015) |
| PCDH10 | Protocadherin 10 | Membrane protein/adhesion molecule | 608286 | Tsai et al. (2012) |
| PLP1 | Myelin proteolipid protein | Membrane protein | 300401 | Kalinowska et al. (2015) |
| PTPN5 | Striatum-enriched protein tyrosine phosphatase (STEP) | Phosphatase | 176879 | Chatterjee et al. (2018) |
| OPHN1 | Oligophrenin 1 | Membrane protein/adhesion molecule | 300127 | Xiao et al. (2013) |
| PPP2CA | Catalytic subunit of protein phosphatase 2 | Phosphatase | 176915 | Bernard et al. (2013) |
| C1Q | Complement Component | Membrane Protein/complement cascade | 120575 | Bie et al. (2019) |
| A2A | A2A receptor | Transmembrane Protein/Receptor | 102776 | Ferrante et al. (2021) |
| Semaphorin 3F | Semaphorin III F | Signalling/secretion | 601124 | Evans et al. (2012) |
| Myf5a | Myogenic Factor 5 | Muscle development | 159990 | Fujita et al. (2017) |
| ADAR2 | Adenosine deaminase RNA-specific 2 | RNA binding protein | 601218 | Filippini et al. (2017) |
| IMP1 | Insulin-like growth factor 2 mRNA-binding protein 1 | RNA transport factor | 608288 | Rackham et al. (2004) |
| TRF-2 | Telomeric repeat binding factor 2 | RNA binding protein | 602027 | Zhang et al. (2015) |
| SIRT1 | Sirtuin 1 | Enzyme/Chromatin silencing factor | 604479 | Yu et al. (2012) |
| Shank1 | Sh3 and multiple ankyrin repeat domains 1 | Scaffolding | 604499 | Zhang et al. (2014) |
| STUB1 | STIP1 homologous and U box-containing protein 1 | E3 ubiquitine ligase/cochaperone | 607207 | — |
| GRK4 | G protein-coupled receptor kinase 4 | serine/threonine kinase | 137026 | Maurin et al., 2015 |
| KCNT1 | Potassium channel subfamily T member 1 | Transmembrane protein/ion channel | 608167 | Brown et al. (2010) |