Table 1.
Identification of HPV16 variants in HNSCC in the literature (PubMed 2000–2020)
| Year publication | Reference | Country | Mean age patients (yrs) | Gender (% male) | Consumption (% active) | Samples | Total cases (n) | Total cases HPV detected %(n) | Total cases HPV16 detected %(n) | Total isolates for HPV sequencing | Genome region location | Amplicon size (pb) | Sequencing |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2000 | [48] | USA | 63 | no data available | 87% | Fresh tissue | 253 | 24% (62) | 90% (56) | 52 | E6 | 455 | Sanger |
| 2004 | [49] | Germany | no data available | no data available | no data available | FF/PE | 24 | 100% (24) | 100% (24) | 21 | E6 and E7 | 793 | Sanger |
| 2007 | [50] | Italy | 63 | 74% | 67% | Fresh tissue FF/PE | 115 | 18% (21) | 67% (14/21) | 13 | L1 | 150 | Sanger |
| 2008 | [51] | USA | 57 | 77% | 76% | Oral rinse FF/PE | 135 | 32% (44) | 100% (44/44) | 19 | E6 | 609 | Sanger |
| 2009 | [52] | Japan | 64 | 86% | 79% | Fresh tissue | 77 | 10% (8) | 100% (8/8) | 8 | E6 | 323 | Sanger |
| 2013 | [53] | Brazil | 59 | 100% | 50% | FF/PE | 4 | 100% (4) | 100% (4/4) | 4 | E6 | no data available | Sanger |
| 2015 | [54] | Italy | 65 | 88% | 63% | FF/PE | 24 | 100% (10) | 100% (10/10) | 10 | E6 | no data available | Sanger |
| 2016 | [55] | USA | 60 | 86% | No data available | FF/PE | 205 | 18% (36) | 70% (25) | 21 | LCR | 193 | Sanger |
| 2020 | [56] | Iran | 56 | 58% | No data available | FF/PE | 108 | 23% (25) | 16% (17) | 13 | E6 | no data available | Sanger |
E6 Early gene 6; E7 early gene 7; LCR long control region; L1 late gene 1; FF/PE Formalin fixed Paraffin embedded