Table 2.
Frequency of HPV16 variants
| Reference | Total cases HPV16 detected (n) | Total isolates HPV sequencing (n) | HPV16 variant region location | European (E) | North American | African | Asian | Asia American | |
|---|---|---|---|---|---|---|---|---|---|
| All lineages (n) | E-350-G (n) | (NA) (n) | (AF1|AF2) (n) | (AS) (n) | (AA) (n) | ||||
| [48] | 56 | 52 | E6 | 39 | 6 | 2 | 2 | 9 | 0 |
| [49] | 24 | 21 | E6 E7 | 15 | 8 | 0 | 0 | 0 | 0 |
| [50] | 14 | 13 | L1 | 9 | 0 | 1 | 2 | 0 | 1 |
| [51] | 44 | 19 | E6 | 18 | 4 | 0 | 0 | 1 | 0 |
| [52] | 8 | 8 | E6 | 5 | 5 | 0 | 0 | 0 | 0 |
| [53] | 4 | 4 | E6 | 2 | 1 | 0 | 0 | 0 | 2 |
| [54] | 10 | 10 | E6 | 8 | 8 | 0 | 0 | 0 | 0 |
| [55] | 25 | 21 | LCR | 9 | – | 0 | 0 | 0 | 12 |
| [56] | 17 | 13 | E6 | 11 | – | 0 | 0 | 0 | 2 |
(–) not evaluated; AA Asia-American HPV16 Variant; AF African HPV16 Variant; AS Asian HPV16 variant; E European HPV16 variant; E6 HPV Early protein 6; E7 HPV Early protein 7; LCR long control region; L1 late gene; NA North American HPV16 Variant