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. 2021 Nov 7;23:104. doi: 10.1186/s13058-021-01481-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — STAT5 in macrophages differentially regulates expression of adaptive immunity-related and tumor-promoting genes. A Heatmap of differentially regulated genes comparing STAT5^fl/fl or STAT5^cKO macrophages treated with No CM, recombinant GM-CSF (rmGM-CSF), or 4T1 CM. B Gene ontology analysis showing pathways altered based on genes that are downregulated in STAT5^cKO macrophages stimulated with rmGM-CSF (left panel) and 4T1 CM (right panel). C, D Gene ontology analysis showing biological processes downregulated and upregulated in 4T1 CM-treated STAT5^cKO BMDMs, respectively. E Positively enriched (red) and negatively enriched (blue) GSEA pathways in 4T1 CM-treated STAT5^cKO BMDMs. F The changes in expression of Epithelial to Mesenchymal Transition (top) and Interferon Gamma Response (bottom) genes in 4T1 CM-treated STAT5^cKO BMDMs analyzed by GSEA