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. 2021 Nov 8;40:351. doi: 10.1186/s13046-021-02155-7

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© The Author(s) 2021, corrected publication 2024

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — LINC01050 expression is up-regulated in gastric cancer tissues and is associated with a poor prognosis. a The top 15 dysregulated lncRNAs in gastric cancer from TCGA data. b Relative expression of LINC01050 in GC tissues compared with noncancerous tissues, based on TCGA data. P < 0.001. c Patients with high expression of LINC01050 showed reduced survival times compared to a low expression of LINC01050 (p = 0.014). d qRT-PCR analysis of LINC01050 expression in a normal gastric epithelium cell line (GES-1) and gastric cancer cell lines (AGS, KATO III, and BGC823). Data are presented as mean ± SD (n = 3). ^**P < 0.01. e qRT-PCR analysis of LINC01050 expression in the nuclear and cytoplasmic fractions from KATO III cells. GAPDH was used as the cytoplasmic control, and U6 as the nucleus control. The data are represented as the mean ± SD (n = 3). f RNA-FISH detection of LINC01050 (red) in GC cell lines (KATO III, BGC823, AGS, and HGC-27) and GES-1 cells. The nuclei were counterstained using DAPI (blue). FISH, fluorescence in situ hybridization. Scale bar = 10 μm