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. 2021 Nov 7;21:598. doi: 10.1186/s12935-021-02305-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — a Knockdown efficiency of EIF4EBP1 was evaluated in NB4 cell line by western blotting. b Knockdown efficiency of EIF4EBP1 was evaluated in NB4 cell line by qPCR. c Knockdown of EIF4EBP1 significantly inhibited the proliferation rates of NB4 cell line. d Knockdown of EIF4EBP1 significantly inhibited the proliferation rates of NB4 cell line. e PARP was increased in NB4 cell line upon knockdown of EIF4EBP1. f Flow cytometry showed that knockdown of EIF4EBP1 increased the apoptotic rates of NB4 cell line. g Knockdown of EIF4EBP1 increased the apoptotic rates of NB4 cell line. h Knockdown efficiency of EIF4EBP1 was evaluated in K562 cell line by western blotting. i Knockdown efficiency of EIF4EBP1 was evaluated in K562 cell line by qPCR. j Knockdown of EIF4EBP1 significantly inhibited the proliferation rates of K562 cell line. k Knockdown of EIF4EBP1 significantly inhibited the proliferation rates of K562 cell line. l PARP was increased in K562 cell line upon knockdown of EIF4EBP1. m Flow cytometry showed that knockdown of EIF4EBP1 increased the apoptotic rates of K562 cell line. n Knockdown of EIF4EBP1 increased the apoptotic rates of K562 cell line