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. 2021 Nov 7;21:1188. doi: 10.1186/s12885-021-08914-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — ANLN, up-regulated in BC, was a target gene of miR-16-5p. a Volcano plot of DEGs from GSE86374. b-e Dot plots of BP (b), CC (c), MF (d) and KEGG (e) enrichment analysis for DEGs. f top of module and hub genes identification from MCODE plug-in of Cytoscape software. g Survival analyses of ANLN in BC by the Kaplan Meier-plotter database. h Expression levels of ANLN in BC comparing to normal tissues. I IHC staining analysis of ANLN in 6 BC tissues. Magnification: × 100, bar = 100 μm. Magnification: × 400, bar = 20 μm. j Target miRNAs of ANLN were predicted by TargetScan, miRWalk and miRDB online databases, and the Venn diagram revealing the intersection. k The nucleotide 810–816 of ANLN 3′UTR that binding site with miR-16-5p by TargetScan. *p < 0.05. BC, breast cancer; DEGs, differentially expressed genes; IHC, Immunohistochemistry; CC, cellular component; MF, molecular function; BP, biological process; KEGG, Kyoto Encyclopedia of Genes and Genomes; FDR, false discovery rate