Figure 4.

Distinct clinical parameters and laboratory markers in association with intrarenal immune cell subtypes. (A) Distinct subtypes of immune cell infiltrates in association with clinical characteristics at disease manifestation of AAV are shown by heatmap reflecting mean values of Spearman’s ρ, asterisks indicate p < 0.05. (B) Distinct subtypes of immune cell infiltrates in association with laboratory parameters at disease manifestation of AAV are shown by heatmap reflecting mean values of Spearman’s ρ, asterisks indicate p < 0.05. AAV, ANCA-associated vasculitis; ANCA, anti-neutrophil cytoplasmic antibodies; BVAS, Birmingham Vasculitis Activity Score; CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; IgG, immunoglobulin G; MPA, microscopic polyangiitis; MPO, myeloperoxidase; RRT, renal replacement therapy; uACR, urinary albumin-to-creatinine ratio; uPCR, urinary protein-to-creatinine ratio.