TABLE 3.

Bivariate correlations between explanatory variables and SF‐36 summary scores

Explanatory variable	SF‐36 PCS		SF‐36 MCS
	Corr. coeff	P	Corr. coeff	P
Age at inclusion (years)	−0.205	.231	0.176	.304
Education >12 years	0.593	<.001	−0.246	.148
Currently employed/student	0.390	.019	−0.049	.776
Female sex	0.097	.572	0.258	.128
Marital status single	−0.122	.478	−0.246	.148
α‐GAL activity <2% of lower ref. limit	−0.373	.025	−0.120	.484
Lyso‐Gb3 (ng/mL)*	−0.412	.014	0.118	.500
Current ERT/chaperone treatment	0.199	.245	0.150	.383
Small fiber neuropathy	−0.341	.048	0.060	.736
BPI pain interference*	−0.814	<.001	−0.010	.953
BPI pain severity average*	−0.651	<.001	0.122	.483
VAS‐P (last 7 days)*	−0.713	<.001	0.146	.396
VAS‐F (last 7 days)*	−0.759	<.001	−0.153	.373
HADS total score*	−0.262	.128	−0.739	<.001
HADS anxiety*	−0.023	.897	−0.616	<.001
HADS depression*	−0.456	.006	−0.655	<.001
Averaged DS3 score*	−0.619	<.001	−0.137	.427
DS3 PNS*	−0.471	.004	−0.102	.554
DS3 renal*	−0.189	.269	0.148	.389
DS3 cardiac*	−0.544	.001	0.150	.383
NYHA class (1‐4)	−0.789	<.001	0.134	.873
DS3 CNS*	−0.185	.281	−0.001	.996
DS3 patient reported*	−0.596	<.001	−0.270	.111

Notes: Pearson/point‐biserial/eta correlation coefficients (*Spearman correlation coefficients for non‐normal distributed or ordinal scale data) between putative explanatory variables and the SF‐36 physical (PCS) and mental (MCS) components scores.

Abbreviations: BPI, brief pain inventory; CNS, central nervous system; ERT, enzyme replacement therapy; HADS, Hospital Anxiety and Depression Score; Lyso‐Gb3, globotriaosylsphingosine; MCS, mental component summary; NYHA, New York Heart Association; PCS, physical component summary; PNS, peripheral nervous system; VAS‐F, fatigue on visual analog scale; VAS‐P, pain on visual analog scale; α‐GAL, alpha galactosidase.

Bold values indicate significant associations by the <0.001 threshold.