TABLE 4.
Factors associated with physical and mental quality of life in patients with Fabry disease. Hierarchical linear regression with bootstrapping
| SF‐36 physical component summary (PCS) | SF‐36 mental component summary (MCS) | |||||
|---|---|---|---|---|---|---|
| β | SE | P | β | SE | P | |
| Model 1 | Adjusted R 2 = 0.332 | Adjusted R 2 = 0.076 | ||||
| Age | −0.146 | 0.121 | .235 | 0.105 | 0.096 | .278 |
| Sex | 2.811 | 3.903 | .455 | 4.654 | 2.851 | .118 |
| Education >12 y | 16.464 | 4.101 | .001 | −4.072 | 2.816 | .156 |
| Model 2 | Adjusted R 2 = 0.488 | Adjusted R 2 = 0.121 | ||||
| Age | 0.027 | 0.108 | .815 | 0.176 | 0.095 | .084 |
| Sex | −1.593 | 3.939 | .702 | 2.834 | 3.251 | .385 |
| Education >12 y | 11.710 | 4.538 | .019 | −6.037 | 3.434 | .099 |
| Global DS3 | −0.950 | 0.330 | .009 | −0.393 | 0.301 | .176 |
| Model 3 | Adjusted R 2 = 0.661 | Adjusted R 2 = 0.555 | ||||
| Age | −0.044 | 0.088 | .600 | 0.137 | 0.076 | .091 |
| Sex | −0.910 | 3.364 | .786 | 2.142 | 2.201 | .345 |
| Education >12 y | 8.477 | 3.783 | .040 | −5.450 | 2.473 | .043 |
| Global DS3 | −0.583 | 0.327 | .079 | −0.025 | 0.211 | .895 |
| Fatigue (VAS‐F) | −1.849 | 0.510 | .002 | 0.179 | 0.443 | .694 |
| Depression (HADS‐D) | −0.437 | 0.415 | .278 | −1.752 | 0.308 | .001 |
Note: With the two SF‐36 component scores (PCS and MCS) as outcomes, demographic variables (age, sex, education) were first included (model 1), then FD‐severity (Global DS3) (model 2) and finally depression (HADS‐D) and fatigue (VAS‐F) (model 3).
Abbreviations: HADS, Hospital Anxiety and Depression Score; VAS, visual analog scale.
Bold values indicate significant associations by the <0.05 threshold.