Table 2.
Frequencies of CYP3A4, CYP3A5, and CYP2D6 genotypes and inferred phenotypes
| Genotypes | Frequency, n | Inferred phenotype | Phenotype frequency, n (%) |
|---|---|---|---|
| CYP3A4 | |||
| *1/*22 | 3 | IM | 3 (6) |
| *1/*1 | 41 | NM | 41 (82) |
| *1/*1B | 6 | RM | 6 (12) |
| CYP3A5 | |||
| *3/*3 | 38 | PM | 40 (80) |
| *3/*7 | 2 | ||
| *1/*3 | 9 | IM | 9 (18) |
| *1/*1 | 1 | NM | 1 (2) |
| CYP2D6 | |||
| *3/*4 | 1 | PM | 8 (16) |
| *4*4 | 6 | ||
| *5/*5 | 1 | ||
| *4/*10 | 1 | ||
| *4/*41 | 1 | IM | 14 (28) |
| *1/*4 | 6 | ||
| *2/*4 | 6 | ||
| (*1/*4)x3* | 2 | IM-NM | 2 (4) |
| *1/*10 | 3 | NM | 24 (48) |
| *1/*29 | 1 | ||
| *1/*41 | 3 | ||
| *1/*1 | 5 | ||
| *1/*2 | 8 | ||
| *2/*2 | 4 | ||
| (*1/*41)x4* | 1 | RM | 2 (4) |
| (*1/*2)x4* | 1 |
IM, intermediate metabolizer; NM, normal metabolizer; PM, poor metabolizer; RM, rapid metabolizer.
*
Denotes number of CYP2D6 alleles (copy number variation).