Table 1 ∣.

Animal models of HFpEF

Animal Model	LVH	HTN	Obesity T2DM	Diastolic Dysfunction	Skeletal Muscle Abnl and/or Exercise Intolerance	Fluid overload >Lung wt	Improved by ACE/ARB
Dahl-salt sensitive rats	++	++	−	++	+	Not pre-HF	+/+
Spontaneously hypertensive rats	++	++	−	+	+	Not pre-HF	+/+
ZSF-1 rat	+	+	+	+	+	+
Aortic constriction (mouse, rat)	+	−	−	+/−	ND	mild	+/+
Aldosterone Infusion (mouse, rat)	+	+	−	++	ND	mild	+
Ageing models (e.g. SAM-WD) mouse	Mild	−	+/−	+	+	−	+
L-Name + HFD, mouse	+	++	+	+	+	+	Not tested
db/db or ob/ob mice	+	+	+	+	+	ND	+
Aged dogs subjected to peri-nephritis-induced hypertension	+	+	−	+	ND	−	Not tested
Aortic Banded Cat	+	++	−	++	ND	+	+
DOCA and salt loaded pigs on HFD	+	+	+	+	+	ND	Not tested

Animal models that focus solely on LV pressure/volume overload such as the Dahl-salt sensitive or spontaneously hypertensive rat, aortic banded cat, or aldosterone infusion – generate principally cardiac disease such as hypertrophy, diastolic dysfunction, and fibrosis. Pure obesity models, such as the leptin or leptin receptor deficient models (db/db or ob/ob) generate marked obseity and some cardiac disease. Other models such as L-NAME+high fat diet (HFD) in mice, or the DOCA-HFD pig model, or the senescence accelerated mouse on western diet (SAM-WD) attempt to integrate both components. The latter two do not develop significant heart failure however, reflected by less increase in diastolic pressure and fluid accumulation in the lungs.