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. 2021 May 10;22(6):bbab134. doi: 10.1093/bib/bbab134

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© The Author(s) 2021. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Overview of the diagnostic process in precision oncology. Within this process, knowledge bases can be attributed to the three main diagnostic steps biological classification of a variant, clinical classification and knowledge bases supporting therapy recommendations. Semi-automatic or manual literature search supports the entire process. The diagnostic process is performed by an interdisciplinary team of physicians and scientists. The exact composition and responsibilities within the team vary between university centers.