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. 2021 Aug 10;114(5):1655–1665. doi: 10.1093/ajcn/nqab243

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© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

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Multivariable-adjusted association between 6-mo changes (Δ) in sACE2 and metabolic health during a diet intervention. (A) Histogram of ΔsACE2 in the entire cohort (n = 457). (B) Multivariable-adjusted change in sACE2 by change in metabolic health profile. Mean ± SE ΔsACE2 was adjusted for sACE2 at baseline, age, sex, and clinical correlates of ΔsACE2 (Table 2) in a linear mixed model and compared using an independent-samples t test. *,**,***Significant changes in sACE2 during follow-up according to paired-sample t test: *P < 0.05,^**P < 0.001, ***P < 0.0001. (C) Multivariable-adjusted risk of decrease in sACE2 by change in metabolic health profile in logistic regression. NPX, normalized protein expression; sACE2, soluble angiotensin-converting enzyme 2.