Table 1.

Existing large-scale anti-cancer drug combination screening datasets

Source	Number of cell lines	Number of tissues	Number of drugs	Number of combinations	Number of data	Experimental design	Synergy metric
AstraZeneca-Sanger DREAM	85	6	118	910	11 576	5 × 5	Loewe score
Merck & Co.	39	6	38	583	23 062	4 × 4	Loewe score
NCI-ALMANAC	60	10	104	5232	304 549	3 × 3 or 5 × 3	ComboScore

The first four columns record the unique number of cell lines, tissues, single drugs and drug combinations included in the dataset. ‘Number of data’ records the sample size of each dataset. ‘Experimental design’ indicates the dosing regimen used by each dataset in the experiments. ‘Synergy metric’ indicates how each dataset defines synergism. NCI, National Cancer Institute.