TABLE 3.
Final Multiple Linear Regression Models for MCI Older Adults.
| Systolic Blood Pressure | ||||||
| Estimate | SE | t-value | p-value | 95%CI | Semi-partial r | |
| Intercept | −2.420 | 0.584 | −4.142 | < 0.001 | −3.571, −1.269 | – |
| DM | −0.239 | 0.609 | −0.392 | 0.696 | −1.438, 0.961 | −0.026 |
| SYS BP | 0.000 | 0.002 | 0.149 | 0.882 | −0.004, 0.004 | 0.010 |
| SYS BP x DM | 0.003 | 0.004 | 0.576 | 0.565 | −0.006, 0.011 | 0.038 |
| Age | 0.030 | 0.005 | 6.577 | < 0.001 | 0.021, 0.039 | 0.400 |
| Gender | 0.061 | 0.074 | 0.825 | 0.410 | −0.085, 0.208 | 0.055 |
| BMI | −0.010 | 0.006 | −1.690 | 0.092 | −0.021, 0.002 | −0.111 |
| CSF Aβ + | 0.122 | 0.069 | 1.773 | 0.078 | −0.014, 0.257 | 0.117 |
| APOE ε4 + | −0.055 | 0.066 | −0.829 | 0.408 | −0.185, 0.076 | −0.055 |
| ICV | 0.001 | 0.000 | 2.839 | 0.005 | 0.000, 0.001 | 0.185 |
|
| ||||||
|
Diastolic Blood Pressure
| ||||||
| Estimate | SE | t-value | p-value | 95%CI | Semi-partial r | |
|
| ||||||
| Intercept | −2.894 | 0.585 | −4.950 | < 0.001 | −4.046, −1.742 | – |
| DM | 1.975 | 0.605 | 3.264 | 0.001 | 0.783, 3.167 | 0.212 |
| DIA BP | 0.007 | 0.003 | 2.243 | 0.026 | 0.001, 0.013 | 0.147 |
| DIA BP x DM | −0.025 | 0.008 | −3.105 | 0.002 | −0.04, −0.009 | −0.202 |
| Age | 0.030 | 0.004 | 6.977 | < 0.001 | 0.022, 0.039 | 0.420 |
| Gender | 0.060 | 0.074 | 0.809 | 0.419 | −0.086, 0.205 | 0.054 |
| BMI | −0.010 | 0.006 | −1.695 | 0.092 | −0.021, 0.002 | −0.112 |
| CSF Aβ + | 0.090 | 0.068 | 1.333 | 0.184 | −0.043, 0.223 | 0.088 |
| APOE ε4 + | −0.051 | 0.065 | −0.797 | 0.426 | −0.179, 0.076 | -0.053 |
| ICV | 0.001 | 0.000 | 2.809 | 0.005 | 0.000, 0.001 | 0.183 |
|
| ||||||
|
Mean Arterial Blood Pressure
| ||||||
| Estimate | SE | t-value | p-value | 95%CI | Semi-partial r | |
|
| ||||||
| Intercept | −2.792 | 0.603 | −4.632 | < 0.001 | −3.980, −1.604 | – |
| DM | 1.232 | 0.720 | 1.712 | 0.088 | −0.186, 2.650 | 0.113 |
| MABP | 0.005 | 0.003 | 1.509 | 0.133 | −0.001, 0.011 | 0.100 |
| MABP x DM | −0.012 | 0.008 | −1.567 | 0.119 | −0.027, 0.003 | −0.103 |
| Age | 0.029 | 0.004 | 6.629 | < 0.001 | 0.021, 0.038 | 0.403 |
| Gender | 0.063 | 0.075 | 0.843 | 0.400 | −0.084, 0.210 | 0.056 |
| BMI | −0.009 | 0.006 | −1.608 | 0.109 | −0.021, 0.002 | −0.106 |
| CSF Aβ + | 0.107 | 0.068 | 1.564 | 0.119 | −0.028, 0.242 | 0.103 |
| APOE ε4 + | −0.049 | 0.066 | −0.745 | 0.457 | −0.178, 0.080 | −0.049 |
| ICV | 0.001 | 0.000 | 2.851 | 0.005 | 0.000, 0.001 | 0.186 |
|
| ||||||
|
Pulse Pressure Index
| ||||||
| Estimate | SE | t-value | p-value | 95%CI | Semi-partial r | |
|
| ||||||
| Intercept | −2.042 | 0.549 | −3.722 | < 0.001 | −3.123, −0.961 | – |
| DM | −1.398 | 0.439 | −3.184 | 0.002 | −2.263, −0.533 | −0.207 |
| PPi | −0.952 | 0.447 | −2.130 | 0.034 | −1.832, −0.071 | −0.140 |
| PPi x DM | 3.480 | 0.994 | 3.501 | 0.001 | 1.521, 5.438 | 0.226 |
| Age | 0.033 | 0.004 | 7.301 | < 0.001 | 0.024, 0.041 | 0.436 |
| Gender | 0.059 | 0.073 | 0.816 | 0.415 | −0.084, 0.203 | 0.054 |
| BMI | −0.011 | 0.006 | −1.962 | 0.051 | −0.022, 0.000 | −0.129 |
| CSF Aβ + | 0.098 | 0.067 | 1.457 | 0.146 | −0.034, 0.230 | 0.096 |
| APOE ε4 + | −0.064 | 0.064 | −0.989 | 0.324 | −0.191, 0.063 | −0.065 |
| ICV | 0.001 | 0.000 | 2.769 | 0.006 | 0.000, 0.001 | 0.181 |
Abbreviations: DM, diabetes; SYS, systolic; DIA, diastolic; BP, blood pressure; MABP, mean arterial blood pressure; PPi, pulse pressure index; BMI, body mass index; CSF Aβ +, cerebrospinal fluid amyloid beta positivity; APOE ε4 +, apolipoprotein E ε4 positivity; ICV, intracranial volume. Bold values indicate for p ≥ 0.05.