Table 2.
Coverage of PAX8 marker gene detection using deconvoluted RNA-seq data
Patient sample | PAX8+ marker coverage | PAX8- marker coverage | ||
---|---|---|---|---|
with scRNA data | without scRNA data | with scRNA data | without scRNA data | |
EOC0939 pAsc | 87% | 94% | 81% | 58% |
EOC1103 pOme1 | 87% | 94% | 82% | 64% |
EOC1103 pPer1 | 87% | 91% | 82% | 70% |
EOC1107 pAsc | 85% | 91% | 78% | 57% |
Coverage was defined as the number of overlapping markers divided by the number of fresh samples markers, where the markers were identified in the fresh tumor samples and after ex vivo culturing using the same marker selection criteria (Wilcoxon test, adjusted P < 0.01 and log fold-change > 1 cutoffs). The total number of PAX8+ and PAX8- markers was 46 and 74, respectively, as detected from the scRNA-seq data of the fresh dissociated tissues.