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. 2021 Oct 25;8:753276. doi: 10.3389/fmolb.2021.753276

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Copyright © 2021 Liu, Chen, Huang, Ma, Huang, Wang and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of the sensitivity of FLT3-F691L detection system. (A) Sensitivity assay of the CRISPR detection system for FLT3-F691L mutation. Plasmids with gradient F691L mutation rates are used as tested samples. The detection was conducted by 15 min of F2R1-mediated RPA and 15 min of L691-crRNA induced Cas12a reaction, both under 37°C. Final fluorescence intensity results and naked-eye results are shown above and below, respectively. The naked-eye results of F691-crRNA induced Cas12a reaction are also shown below. (B) Time-course analysis of the L691-crRNA induced Cas12a reaction in (A).