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. 2021 Oct 29;218(12):e20210924. doi: 10.1084/jem.20210924

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© 2021 Zhang et al.

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Figure 6. — Comparison of gene expressions between RNA-seq of Lyve1^hi membrane-associated macrophages and scRNA-seq of Lyve1^hi omental macrophages in ovarian tumor progression. (A) Reanalyzed uniform manifold approximation and projection (UMAP) plot of scRNA-seq data (ArrayExpress accession no. E-MTAB-8593) of F4/80⁺ CD64⁺ omental macrophages isolated 10 wk after ID8 ovarian tumor cell injection. (B) Violin plot of Timd4 and Lyve1 expression from the scRNA-seq dataset in A. (C) UMAP plot of scRNA-seq showing top 100 genes up-regulated in bulk RNA-seq datasets of LYVE1^hi membrane-associated macrophages. (D) GSEA of RNA-seq data from Lyve1^hi membrane-associated macrophages showing select genes enriched in Cluster 10 of scRNA-seq. NES, normalized enrichment score.