Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 4;22(6):bbab214. doi: 10.1093/bib/bbab214

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

PMC Copyright notice

tpGWAS revealed different patterns of module distribution in 20 brain-related disorders or traits. In each panel, a dot represents a module. The x-axis is the normalized node score from , which is calculated using gene-based P-value from GWAS. The y-axis is the normalized edge score from , which is calculated using gene co-expression. Normalization was conducted using random modules, which are not shown in the figure, but the 95% confidence interval estimated by using random modules is shown as the red eclipse. Color dots indicate significant modules selected to define module genes. The horizontal and vertical gray dash lines indicate where x = 1.68 or y = 1.68 (95% of modules having the scores below the line). ANX, anxiety; COL, college.

Inline graphic — tpGWAS revealed different patterns of module distribution in 20 brain-related disorders or traits. In each panel, a dot represents a module. The x-axis is the normalized node score from , which is calculated using gene-based P-value from GWAS. The y-axis is the normalized edge score from , which is calculated using gene co-expression. Normalization was conducted using random modules, which are not shown in the figure, but the 95% confidence interval estimated by using random modules is shown as the red eclipse. Color dots indicate significant modules selected to define module genes. The horizontal and vertical gray dash lines indicate where x = 1.68 or y = 1.68 (95% of modules having the scores below the line). ANX, anxiety; COL, college.