Table 2.
HRs and 95% CIs of colon cancer according to moderate to vigorous physical activity among individuals with and without diabetes in the NIH-AARP Diet and Health Study.
| Moderate to vigorous physical activity | ||||||
|---|---|---|---|---|---|---|
|
| ||||||
| Never/rarely | Never/rarely to <1 hr/wk | 1 to 3 hrs/wk | 4 to 7 hrs/wk | >7 hrs/wk | P trend | |
| Diabetics | ||||||
| Total colon cancer | ||||||
| Person-years | 64,678 | 36,930 | 75,983 | 64,837 | 54,888 | |
| Cases | 113 | 61 | 116 | 115 | 75 | |
| Age- and sex-adjusted HR (95% CI) | 1.00 | 0.95 (0.70–1.30) | 0.86 (0.66–1.12) | 0.99 (0.76–1.28) | 0.74 (0.56–0.996) | .16 |
| Multivariable-adjusted HR (95% CI) | 1.00 | 0.98 (0.72–1.34) | 0.89 (0.69–1.16) | 1.03 (0.80–1.35) | 0.78 (0.58–1.05) | .29 |
| Multivariable- and BMI-adjusted HR (95% CI) | 1.00 | 0.99 (0.72–1.35) | 0.91 (0.70–1.19) | 1.07 (0.82–1.39) | 0.81 (0.60–1.09) | .45 |
| Proximal colon cancer | ||||||
| Cases | 72 | 40 | 59 | 76 | 44 | |
| Age- and sex-adjusted HR (95% CI) | 1.00 | 0.98 (0.66–1.44) | 0.68 (0.48–0.96) | 1.02 (0.74–1.40) | 0.68 (0.46–0.98) | .27 |
| Multivariable-adjusted HR (95% CI) | 1.00 | 0.98 (0.67–1.45) | 0.69 (0.49–0.97) | 1.03 (0.74–1.43) | 0.69 (0.47–1.01) | .32 |
| Multivariable- and BMI-adjusted HR (95% CI) | 1.00 | 0.99 (0.67–1.47) | 0.71 (0.50–0.998) | 1.07 (0.77–1.49) | 0.72 (0.49–1.06) | .47 |
| Distal colon cancer | ||||||
| Cases | 36 | 20 | 52 | 33 | 28 | |
| Age- and sex-adjusted HR (95% CI) | 1.00 | 0.99 (0.57–1.70) | 1.23 (0.80–1.88) | 0.90 (0.56–1.45) | 0.89 (0.55–1.47) | .37 |
| Multivariable-adjusted HR (95% CI) | 1.00 | 1.04 (0.60–1.80) | 1.32 (0.86–2.02) | 0.98 (0.61–1.58) | 0.96 (0.58–1.59) | .53 |
| Multivariable- and BMI-adjusted HR (95% CI) | 1.00 | 1.05 (0.61–1.82) | 1.34 (0.87–2.06) | 1.01 (0.62–1.63) | 0.996 (0.60–1.65) | .62 |
| Non-diabetics | ||||||
| Total colon cancer | ||||||
| Person-years | 474,947 | 372,947 | 913,040 | 952,944 | 897,043 | |
| Cases | 664 | 462 | 1069 | 981 | 975 | |
| Age- and sex-adjusted HR (95% CI) | 1.00 | 0.91 (0.81–1.02) | 0.84 (0.76–0.93) | 0.72 (0.65–0.79) | 0.74 (0.67–0.81) | <.001 |
| Multivariable-adjusted HR (95% CI) | 1.00 | 0.94 (0.84–1.06) | 0.90 (0.82–0.99) | 0.79 (0.71–0.87) | 0.81 (0.73–0.89) | <.001 |
| Multivariable- and BMI-adjusted HR (95% CI) | 1.00 | 0.94 (0.84–1.06) | 0.91 (0.82–1.002) | 0.80 (0.73–0.89) | 0.83 (0.75–0.91) | <.001 |
| Proximal colon cancer | ||||||
| Cases | 394 | 271 | 655 | 644 | 559 | |
| Age- and sex-adjusted HR (95% CI) | 1.00 | 0.90 (0.77–1.05) | 0.87 (0.77–0.98) | 0.79 (0.70–0.90) | 0.71 (0.62–0.81) | <.001 |
| Multivariable-adjusted HR (95% CI) | 1.00 | 0.93 (0.79–1.08) | 0.92 (0.81–1.04) | 0.85 (0.75–0.97) | 0.76 (0.67–0.87) | <.001 |
| Multivariable- and BMI-adjusted HR (95% CI) | 1.00 | 0.93 (0.80–1.09) | 0.93 (0.82–1.05) | 0.87 (0.76–0.99) | 0.78 (0.68–0.89) | <.001 |
| Distal colon cancer | ||||||
| Cases | 242 | 174 | 381 | 314 | 382 | |
| Age- and sex-adjusted HR (95% CI) | 1.00 | 0.94 (0.77–1.14) | 0.83 (0.70–0.97) | 0.64 (0.54–0.75) | 0.80 (0.68–0.94) | <.001 |
| Multivariable-adjusted HR (95% CI) | 1.00 | 0.98 (0.81–1.19) | 0.90 (0.77–1.06) | 0.72 (0.61–0.85) | 0.90 (0.76–1.06) | .02 |
| Multivariable- and BMI-adjusted HR (95% CI) | 1.00 | 0.98 (0.81–1.20) | 0.91 (0.77–1.07) | 0.73 (0.62–0.87) | 0.93 (0.78–1.09) | .07 |
HR=hazard ratio; CI=confidence interval; BMI= body mass index. Multivariable-adjusted HRs (95% CIs) are adjusted for age, sex, race/ethnicity, education, smoking status, family history of colon cancer, hormone replacement therapy use (women only), non-steroidal anti-inflammatory drug use, total fiber intake, red meat intake, and alcohol consumption.