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. 2021 Jul 9;22(6):bbab250. doi: 10.1093/bib/bbab250

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© The Author(s) 2021. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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The joint pattern of DNA sequence and methylation decides the prediction of DISMIR. (A) The relationship between methylation rates and d-scores of all reads. (B) The relationship of d-scores of raw reads and their RC reads. (C) The schematic diagram depicting how reads with altered methylation states were generated for downstream analysis. (D) Δsingled-score (blue line) and the corresponding demethylation rate (gray line) at different positions in the selected switching region. Colored shadows show the standard deviation of Δsingled-score. (E) Δalld-score (red line), Δsumd-score (green line) and the corresponding CpG count (gray line) at different positions in the selected switching region.