Figure 5 .

DISMIR and its kernels can resist to methylation state alterations of single CpG sites. (A) The distribution of Δalld-scores and Δsumd-scores of all reads (left) and certain kernel-activated reads (middle and right). The black lines are diagonal lines where Δalld-scores are equal to Δsumd-scores. (B) The cumulative distribution function of Δalld-scores and Δsumd-scores of reads shown in (A). ES of the Mann–Whitney U test are shown. (C) The distribution of ES of the Mann–Whitney U test for Δalld-scores and Δsumd-scores of reads activated by certain kernels in comparison with them of all reads, which was performed the same as shown in (B). For (A) and (B), results of reads with three CpG sites were shown. For (C), results of reads with three, four and five CpG sites were shown with performing model training for 10 times. Black lines show where ES equals to 0.5 and divide the plane into four quadrants.