Table 1.

Summary of simulation scenarios

Scenario Notationa	Handling effects in training data	Handling effects in test data	Handling effects associated with outcome in training data	Handling effects associated with outcome in test data
HE00Asso00	No	No	No	No
HE10Asso00	Yes	No	No	No
HE10Asso10	Yes	No	Yes	No
HE11Asso00	Yes	Yes	No	No
HE11Asso10	Yes	Yes	Yes	No
HE11Asso01	Yes	Yes	No	Yes
HE11Asso11	Yes	Yes	Yes	Yes
HE11Asso1-1	Yes	Yes	Yes	Yes (negatively)

^a‘HE’ stands for handling effects. The 1st and 2nd digits following ‘HE’ indicate presence (‘1’) versus absence (‘0’) of handling effects in training and test data, respectively. ‘Asso’ stands for association with survival outcome. The 1st and 2nd digits following ‘Asso’ indicate the presence (‘1’ = positive, ‘-1’ = negative) versus absence (‘0’) of association between handling effects and survival outcome in training and test data, respectively.