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. 2021 Aug 17;22(6):bbab315. doi: 10.1093/bib/bbab315

Table 9.

The top pathways for differentiating LumB and Basal (BRCA subtypes), using the Broad Institute’s curated pathway database

Pathway Genes in overlap Inline graphic -value
Genes up-regulated in breast cancer samples positive for ESR1 compared to the ESR1 negative tumours 27 1.15e-47
Genes down-regulated in basal subtype of breast cancer samples 39 4.25e-43
Genes up-regulated in bone relapse of breast cancer 24 2.6e-42
Genes that best discriminated between two groups of breast cancer according to the status of ESR1 and AR basal (ESR1- AR-) and luminal (ESR1+ AR+) 29 1.85e-37
Genes up-regulated in luminal-like breast cancer cell lines compared to the basal-like ones 26 1.82e-30