Figure 3.

Summary of the most important known and speculated differences between UC1 and UC2 patient groups. Patients in the cluster UC1 show generally higher expression of genes related to neutrophil infiltration and degranulation as well as cytokine signalling, whereas gene expression signature in the cluster UC2 suggests high B cell activation.¹⁴³ Further, patients in the cluster UC2 are more responsive to both infliximab and vedolizumab compared with patients in the UC2 cluster.¹⁴³ UC, ulcerative colitis; IL, interleukin; TNF, tumour necrosis factors; TREM, triggering receptor expressed on myeloid cells; S100A8, S100 calcium binding protein A8; BCL2A1, B cell lymphoma 2 associated protein A1; CYP26B1, cytochrome P450 26B1; NOX, nicotinamide adenine dinucleotide phosphate oxidase; NR3C2, nuclear receptor subfamily 3 group C member 2; PARM, prostate androgen- regulated mucin-like protein.