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. 2021 May 7;15(11):1959–1973. doi: 10.1093/ecco-jcc/jjab085

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© The Author(s) 2021. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Illustration of the function of genes differentially upregulated in UC1 compared with UC2 patients in the context of gut inflammation. The genes that are differentially upregulated are related to innate immunity and neutrophil activation, migration of immune cells, cell-cell cross-talk in inflammation, tissue regeneration, and ECM remodelling.¹¹⁸ Thus, it may be that these functions are more highly activated in UC1 than UC2 patients. However, this hypothesis should be confirmed in future studies. UC, ulcerative colitis; Th, T helper cell; B, B cell; ECM, extracellular matrix.