Figure 4.

Association analysis results for African-American ancestry cohort, showing odds ratios for mortality from acute COVID-19 in the presence or absence of biomarkers for severe disease. The genetic risk factors (coded as “Pos” and shown as red bars) are IRF7 region rs4963128 C allele carriers and rs702966 G allele carriers. Subjects who do not carry any one of these alleles are coded as “Neg” and shown as blue bars. The biomarker risk factors include D-Dimer>560 ng/mL, CRP>115 mg/L, and Troponin>0.01 ng/mL, and each biomarker above these thresholds was weighted as 1 positive biomarker. All odds ratios and hypothesis test p-values were calculated for mortality risk with respect to the lowest risk group (gene negative and biomarker negative). Dashed lines showing the minimum threshold for 95% statistical confidence are shown in red.