Table 10.
Demographic data and comorbidities according to use of macrolides
| Total (n = 13,932) | No. (%) | With macrolides n = 8382 (%) | Without macrolides n = 5502 (%) | p value | |
|---|---|---|---|---|---|
| Median (IQR) age (years) | 69 (56–80) [18–105] | 68 (56–79) | 71 (57–82) | < 0.001 | |
| Age (years) | |||||
| < 40 years | 13,884 | 882 (6.4) | 483 (5.8) | 399 (7.3) | < 0.001* |
| 40–50 years | 1359 (9.8) | 843 (10.1) | 516 (9.4) | ||
| 50–60 years | 2199 (15.8) | 1418 (16.9) | 781 (14.2) | ||
| 60–70 years | 2708 (19.5) | 1756 (21.0) | 952 (17.3) | ||
| 70–80 years | 3318 (23.9) | 2024 (24.15) | 1294 (23.5) | ||
| > 80 years | 3418 (24.6) | 1858 (22.2) | 1560 (28.4) | ||
| Sex | |||||
| Women | 13,869 | 5953 (42.9) | 3464 (41.4) | 2489 (45.3) | < 0.001 |
| Men | 7916 (57.1) | 4912 (58.6) | 3004 (54.7) | ||
| Hypertension | 13,862 | 7010 (50.6) | 4223 (50.5) | 2787 (50.8) | 0.74 |
| Diabetes Mellitus | 13,838 | 2645 (19.1) | 1550 (18.5) | 1095 (20.0) | 0.033 |
| Dyslipidemia | 13,856 | 5479 (39.5) | 3326 (39.8) | 2153 (39.2) | 0.53 |
| Obesity (BMI > 30) | 6287 | 2128 (33.9) | 1387 (35.4) | 741 (31.3) | 0.001 |
| Smoking status | |||||
| Never | 13,214 | 9212 (69.7) | 5522 (68.9) | 3690 (71.0) | 0.021 |
| Former | 3299 (25.0) | 2083 (26.0) | 1216 (23.4) | ||
| Current | 703 (5.3) | 413 (5.2) | 290 (5.6) | ||
| Alcohol use disorder | 13,412 | 624 (4.7) | 380 (4.7) | 244 (4.6) | 0.82 |
| Atrial fibrillation | 13,851 | 1552 (11.2) | 837 (10.0) | 715 (13.0) | < 0.001 |
| Myocardial infarction | 13,849 | 1103 (8.0) | 625 (7.5) | 478 (8.7) | 0.009 |
| Congestive heart failure | 13,855 | 988 (7.1) | 518 (6.2) | 470 (8.6) | < 0.001 |
| Chronic pulmonary disease | 13,856 | 948 (6.8) | 519 (6.2) | 429 (7.8) | < 0.001 |
| Chronic bronchitis | 13,855 | 703 (5.1) | 424 (5.1) | 279 (5.1) | 0.96 |
| Asthma | 13,853 | 1010 (7.3) | 623 (7.5) | 387 (7.1) | 0.38 |
| Obstructive sleep apnea syndrome | 13,791 | 846 (6.1) | 549 (6.6) | 297 (5.4) | 0.006 |
| Peripheral vascular disease | 13,848 | 652 (4.7) | 383 (4.6) | 269 (4.9) | 0.39 |
| Dementia | 13,852 | 1392 (10.1) | 691 (8.3) | 701 (12.8) | < 0.001 |
| Cerebrovascular disease | 13,837 | 994 (7.2) | 553 (6.6) | 441 (8.0) | 0.002 |
| Hemiplegia | 13,863 | 228 (1.6) | 119 (1.4) | 109 (2.0) | 0.011 |
| Neurodegenerative disease | 13,860 | 1268 (9.2) | 610 (7.3) | 658 (12.0) | < 0.001 |
| Chronic kidney disease | 13,851 | 828 (6.0) | 493 (5.9) | 335 (6.1) | 0.62 |
| Dialysis | 13,826 | 140 (1.0) | 78 (0.9) | 62 (1.1) | 0.011 |
| Chronic liver disease | 13,821 | 511 (3.7) | 298 (3.6) | 213 (3.9) | 0.33 |
| Cancer | 13,842 | 1128 (8.2) | 602 (7.2) | 526 (9.6) | < 0.001 |
| Solid metastatic tumor | 13,852 | 284 (2.1) | 147 (1.8) | 137 (2.5) | 0.003 |
| Leukemia | 13,864 | 169 (1.2) | 107 (1.3) | 62 (1.1) | 0.43 |
| Lymphoma | 13,854 | 198 (1.4) | 94 (1.1) | 104 (1.9) | < 0.001 |
| Peptic ulcer | 13,848 | 353 (2.6) | 208 (2.5) | 145 (2.6) | 0.58 |
| Rare disease | 13,821 | 280 (2.0) | 133 (1.6) | 147 (2.7) | < 0.001 |
| Rheumatic disease | 13,844 | 321 (2.3) | 184 (2.2) | 137 (2.5) | 0.26 |
| Organ transplantation | 13,708 | 170 (1.2) | 97 (1.2) | 73 (1.4) | 0.37 |
| HIV infection | 13,825 | 97 (0.7) | 55 (0.7) | 42 (0.8) | 0.46 |
| Acquired immunodeficiency syndrome (AIDS) | 13,828 | 40 (0.3) | 26 (0.3) | 14 (0.3) | 0.55 |
| Degree of dependence | |||||
| Independent or mild | 13,680 | 11,415 (83.4) | 7093 (85.8) | 4322 (79.9) | < 0.001 |
| Moderate | 1283 (9.4) | 703 (8.5) | 580 (10.7) | ||
| Severe | 982 (7.2) | 473 (5.7) | 509 (9.4) | ||
| Charlson Comorbidity Index, median (IQR) | 13,511 | 1 (0–2) | 1 (0–2) | 1 (0–2) | < 0.001 |
| Age-adjusted Charlson Comorbidity Index, median (IQR) | 3 (2–5) | 3 (1–5) | 4 (2–6) | < 0.001 | |
*Mann–Whitney U test