Table 20.
Laboratory outcomes after using macrolides
| 1 week after admission | Total (n = 13,932) | No. (%) | With macrolides n = 8382 (%) | Without macrolides n = 5502 (%) | Odds ratio (95% CI) | No. Total (n = 13,932) |
|---|---|---|---|---|---|---|
| Anemia (Hb < 12 g/dL) | 12,778 | 3800 (29.7) | 2346 (29.8) | 3439 (29.7) | 1.00 (0.93–1.08) | 0.97 |
| Thrombocytosis (Platelet count > 180) | 12,763 | 10,293 (80.7) | 6504 (82.6) | 3789 (77.6) | 1.37 (1.25–1.50) | < 0.001 |
| Leukocytosis (Leukocytes > 10,000) | 12,776 | 2439 (19.1) | 1611 (20.4) | 828 (16.9) | 1.26 (1.15–1.38) | < 0.001 |
| Leukopenia (Leukocytes < 4000) | 11,262 (88.2) | 7008 (88.9) | 4254 (87.0) | 1.19 (1.07–1.33) | 0.001 | |
| Lymphopenia (Lymphocytes < 1300) | 12,758 | 4844 (38.0) | 3006 (38.2) | 1838 (37.6) | 1.02 (0.95–1.10) | 0.55 |
| Evolution of inflammatory parameters associated with COVID-19 | ||||||
| C-reactive protein > 50 mg/L | 12,375 | 4102 (33.2) | 2418 (31.6) | 1684 (35.7) | 0.83 (0.77–0.90) | < 0.001 |
| Procalcitonin > 0.5 ng/mL | 4970 | 621 (12.5) | 368 (12.6) | 253 (12.3) | 1.03 (0.86–1.22) | 0.77 |
| Ferritin > 274 mcg/L | 6196 | 5010 (80.9) | 3376 (80.7) | 1634 (81.2) | 0.97 (0.84–1.11) | 0.62 |
| Fibrinogen > 650 mg/dL | 7927 | 2953 (37.3) | 1622 (34.6) | 1331 (41.0) | 0.76 (0.69–0.83) | < 0.001 |
| CK > 200 U/L | 5828 | 706 (12.1) | 426 (11.6) | 280 (12.9) | 0.89 (0.76–1.04) | 0.15 |
| LDH > 300 U/L | 11,385 | 5065 (44.5) | 3271 (45.9) | 1794 (42.2) | 1.16 (1.08–1.25) | < 0.001 |
| IL-6 > 4.3 pg/mL | 2097 | 1613 (76.9) | 1124 (76.1) | 489 (79) | 0.84 (0.67–1.06) | 0.14 |
| D-dimer > 250 ng/mL | 9698 | 8452 (87.2) | 5462 (89.6) | 2990 (83.0) | 1.77 (1.57–1.99) | < 0.001 |