Table 22.
Decision to start antibiotic therapy (and which one) based on initial inflammatory parameters
| On admission | Beta-lactams | Macrolides | Quinolones | |||
|---|---|---|---|---|---|---|
| No (Total) | N. (%) | No (Total) | N. (%) | No (Total) | N. (%) | |
| Anemia (Hb < 12 g/dL) | 2368 | 1737 (73.4) | 2364 | 1339 (56.6) | 2346 | 330 (14.1) |
| Thrombocytosis (Platelet count > 180) | 7627 | 5462 (71.6) | 7619 | 4709 (61.8) | 7556 | 977 (12.9) |
| Leukocytosis (Leukocytes > 10,000 | 2098 | 1602 (76.4) | 2094 | 1222 (58.4) | 2084 | 317 (15.2) |
| Leukopenia (Leukocytes < 4000) | 1903 | 1333 (70.1) | 1901 | 1114 (58.6) | 1884 | 275 (14.6) |
| Lymphopenia (Lymphocytes < 1300) | 10,500 | 7832 (74.6) | 10,492 | 6432 (61.30) | 10,412 | 1445 (13.9) |
| C-reactive protein > 50 mg/L | 7214 | 5653 (78.4) | 7212 | 4557 (63.2) | 7154 | 1012 (14.2) |
| Procalcitonin > 0.5 ng/mL | 776 | 651 (83.9) | 774 | 445 (57.5) | 768 | 110 (14.3) |
| Ferritin > 274 mcg/L | 4118 | 3021 (73.4) | 4117 | 2869 (69.7) | 4099 | 390 (9.5) |
| Fibrinogen > 650 mg/dL | 3749 | 2856 (76.2) | 3751 | 2162 (57.6) | 3720 | 432 (11.6) |
| CK > 200 U/L | 1459 | 1151 (78.9) | 1454 | 927 (63.8) | 1444 | 199 (13.8) |
| LDH > 300 U/L | 6647 | 5052 (76.0) | 6641 | 4381 (66.0) | 6588 | 824 (12.5) |
| IL-6 > 4.3 pg/mL | 1563 | 1160 (74.2) | 1564 | 1111 (71.0) | 1556 | 110 (7.1) |
| D-dimer > 250 ng/mL | 9313 | 6652 (71.4) | 9318 | 6032 (64.7) | 9247 | 1158 (12.5) |