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. Author manuscript; available in PMC: 2021 Nov 8.
Published in final edited form as: Arch Pathol Lab Med. 2019 Nov 13;144(6):725–734. doi: 10.5858/arpa.2019-0241-OA

Table 4.

The Relationships of Community Pathology (CP)–Diagnosed Cervical Intraepithelial Neoplasia Grade 2 (CIN2), Stratified by p16 Immunohistochemistry (IHC) Results and Antecedent Cytologic Interpretation Categorized as High-Grade Squamous Intraepithelial Lesion (HSIL) or More Severe (HSIL+) Versus Not (<HSIL), With Human Papillomavirus (HPV) Categories and Compared to CP-Diagnosed CIN3

HPV Risk Groupa CP-Diagnosed CIN2
p16 IHC Negative p16 IHC Positive
<HSIL Cytology HSIL+ Cytology <HSIL Cytology HSIL+ Cytology
N % Col N % Col N % Col N % Col
HPV16 61 20.4 18 22.5 284 36.7 88 42.7
HPV18/45 16 5.4 9 11.3 54 7.0 17 8.3
Other high riskb 127 42.5 28 35.0 360 46.5 87 42.2
Intermediate riskc 21 7.0 5 6.3 46 5.9 8 3.9
Low riskd 15 5.0 1 1.3 6 0.8 0 0.0
HPV negative 59 19.7 19 23.8 24 3.1 6 2.9
Ptrend (versus CIN3e) <.001 <.001 <.001 .012

One hundred fifty-three cases were missing antecedent cytology results. “% Col” is the column percentage, that is, the number in cell divided by the total column number.

a

Defined hierarchically according to cancer risk.

b

HPV31, 33, 35, 39, 51, 52, 56, 58, 59, and 68.

c

HPV26, 53, 66, 67, 70, 73, and 82.

d

HPV6, 11, 40, 42, 54, 55, 61, 62, 64, 69, 71, 72, 81, 82v, 83, 84, and 89.

e

Compared to data combining p16 IHC–negative and p16 IHC–positive CIN3 from Table 1.