Fig 1. Transmission of Taenia solium in CystiAgent.
Panel A (top): 1) Live pig trade: infected (live) pigs are sold to other households inside and outside the village, and imported from outside; 2) in-house slaughter and sale of pork to other households 3) pork consumption: potentially infected pork is consumed by household members; 4) human infection (see panel B for details); 5) human travel: humans travel to other endemic villages where they may acquire tapeworm infections through pork consumption; 6) open defecation: humans may practice open outdoor defecation; 7) pig roaming and foraging: free-roaming pigs consume potentially infectious eggs present in the environment; 8) pig infection (see panel B for details). Panel B (bottom): Susceptible pigs (S) may be heavily exposed (EH) by consuming T. solium proglottid segments in the environment or through the stochastic parameter heavy-all, which is a probability of exposure applied to all pigs, or be lightly exposed (EL) by consuming T. solium eggs in the environment or through light-all. Pigs with heavy or light exposure may develop heavy (IH) or light (IL) cyst infection through the stochastic tuning parameters light-inf and heavy-inf. Pigs with heavy or light exposure may become seropositive (IS) based on the stochastic tuning parameters light-sero and heavy-sero. Susceptible humans (S) may be heavily exposed (EH) or lightly (EL) exposed to cysts after eating infected pork from a heavily or lightly infected pig. Consumption of heavily or lightly infected pork cause tapeworm infection (I) in humans based on the stochastic tuning parameters ph2h and pl2h, respectively. Icons provided by Noun Project and created by Pariphat Sinma, Ikopah, Dennis, Berkah, Giorgiana Ionescu, Nabilauzwa and Alexsandr Vector.