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. 2021 Nov 4;16:7433–7447. doi: 10.2147/IJN.S327737

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© 2021 Yan et al.

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The BBB opening and drug permeability by Cur-NBs combined with LIFU. (A) Schematic representation of the BBB opening by Cur-NBs combined with LIFU. (B) Evaluation of BBB opening at the various acoustic intensities (0, 0.24, 0.31, 0.38 and 0.45MPa) by Cur-NBs combined with LIFU. (Cortex: cerebral cortex; Striatum: corpus striatum). Scale bar is 250 μm. (C and D) Quantitative analysis of fluorescent intensities of Evans blue and curcumin for each group. **P < 0.01 and ***P < 0.001 vs 0 MPa group, ^##P < 0.01 and ^###P < 0.001 between two groups.