Table 4.
Symptom | Fraction of Patients Scoring Symptom Impact as “Severe” or “Overwhelming” | ||||
---|---|---|---|---|---|
Baseline | 3 Months | 6 Months | 9 Months | 12 Months | |
Poor mobility | 30% | 25% | 21% | 25% | 29% |
Weakness or lack of energy | 28% | 16% | 15% | 20% | 16% |
Sore or dry mouth | 20% | 18% | 11% | 9% | 13% |
Difficulty sleeping | 16% | 4% | 13% | 13% | 18% |
Itching | 15% | 4% | 11% | 9% | 7% |
Pain | 14% | 4% | 4% | 14% | 13% |
Shortness of breath | 13% | 6% | 8% | 5% | 13% |
Drowsiness | 9% | 8% | 8% | 13% | 9% |
Feeling depressed | 9% | 4% | 8% | 7% | 7% |
Restless legs or difficulty keeping legs still | 8% | 2% | 9% | 4% | 11% |
Feeling anxious or worried | 8% | 2% | 6% | 2% | 7% |
Changes in skin | 5% | 4% | 4% | 7% | 5% |
Constipation | 2% | 6% | 6% | 4% | 4% |
Poor appetite | 2% | 2% | 2% | 2% | 5% |
Diarrhea | 2% | 0% | 2% | 2% | 2% |
Nausea | 2% | 2% | 0% | 2% | 0% |
Vomiting | 2% | 2% | 0% | 0% | 0% |
Note: Symptoms are ordered by prevalence at the baseline assessment.