Table 3.

Cox proportional hazards regression analyses of ACM and CSM in patients with primary cardiac sarcoma

Variable	Univariable analysis			Multiple analysis
	HR	95% CI	P-value	HR	95% CI	P-value
For ACM
Age*	1.929	1.419–2.622	<0.001	2.083	1.507–2.877	<0.001
Year of diagnosis#	0.703	0.497–0.996	0.048	0.632	0.435–0.920	0.016
Size of tumor	1.179	0.947–1.468	0.141
Number of tumors	0.908	0.534–1.544	0.722
SEER stage	0.847	0.711–1.000	0.062	0.706	0.578–0.862	0.001
Radiation therapy	1.120	0.802–1.565	0.506
Chemotherapy	0.593	0.436–0.806	0.001	0.483	0.340–0.687	<0.001
Surgery	0.614	0.447–0.845	0.003	0.595	0.422–0.840	0.003
For CSM
Age*	1.709	1.226–2.381	0.002	1.898	1.338–2.693	<0.001
Year of diagnosis#	0.653	0.451–0.944	0.023	0.589	0.396–0.877	0.009
Classification&	-	-	0.541
Size of tumor	1.319	1.037–1.678	0.024
Number of tumors	-	-	1.000
SEER stage	0.802	0.663–0.969	0.022	0.673	0.541–0.837	0.003
Radiation therapy	1.079	0.750–1.552	0.681
Chemotherapy	0.619	0.445–0.862	0.005	0.479	0.327–0.700	<0.001
Surgery	0.565	0.403–0.794	0.001	0.564	0.390–0.816	0.002

^*Age <50 or ≥50

^#Year of diagnosis <2000 or ≥2000

^&Classification angiomyosarcoma or leiomyosarcoma or myxoid sarcoma or other types

ACM - 1-year all-cause mortality; CSM - 1-year cancer-specific mortality; HR - hazard ratio; CI - confidence interval