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Schematic representation of different technological approaches to study genetic and epigenetic alterations in penile cancer (A) gene dosage analysis and detection of copy number alterations, (B) mutational profiling, (C) DNA methylation changes, and (D) transcriptomic and integrated pathways analysis. Representative examples of genes involved in the development and progression of PeSCC are indicated in rectangles. PeSCC, penile squamous cell carcinoma.
