Table 2. The heart-specific and all-cause mortality rates of patients with BCa undergoing RC, RT, or CT were standardized by age and cancer stage relative to the general population.

Group	SMR heart-specific (95% CI)				SMR overall (95% CI)
	RC	RT/RT + CT	CT		RC	RT/RT + CT	CT
Age
50–54	2.72 (1.41, 5.22)	4.49 (1.12, 17.97)	1.27 (0.53, 3.06)		24.42 (22.13, 26.93)	76.56 (65.81, 89.06)	14.04 (12.46, 15.81)
55–59	2.92 (1.94, 4.39)	2.54 (0.82, 7.88)	1.76 (1.09, 2.83)		16.55 (15.3, 17.91)	49.9 (44.38, 56.1)	10.72 (9.82, 11.71)
60–64	2.6 (1.91, 3.54)	4.36 (2.41, 7.87)	2.35 (1.76, 3.15)		12.22 (11.43, 13.07)	31.05 (28, 34.44)	7.41 (6.86, 8)
65–69	2.75 (2.16, 3.5)	7.53 (5.46, 10.39)	1.88 (1.46, 2.41)		9.21 (8.66, 9.79)	21.72 (19.88, 23.72)	5.28 (4.92, 5.66)
70–74	2.18 (1.74, 2.73)	6.44 (4.98, 8.33)	1.79 (1.45, 2.21)		6.62 (6.23, 7.03)	15.57 (14.42, 16.82)	3.93 (3.67, 4.19)
75–79	1.91 (1.56, 2.33)	4.33 (3.49, 5.38)	2 (1.71, 2.35)		4.54 (4.27, 4.84)	10.86 (10.18, 11.58)	2.93 (2.76, 3.12)
80–85	1.63 (1.35, 1.98)	3.44 (2.92, 4.04)	1.54 (1.33, 1.79)		3.35 (3.13, 3.58)	6.64 (6.27, 7.03)	2.25 (2.12, 2.4)
Stage
In situ	2.93 (1.67, 5.16)	2.69 (1.21, 5.98)	1.35 (1.18, 1.54)		2.48 (1.85, 3.32)	3.63 (2.61, 5.06)	1.07 (1, 1.15)
Local	1.65 (1.42, 1.92)	4.41 (3.9, 4.99)	2.14 (1.89, 2.43)		3.31 (3.14, 3.48)	8.26 (7.91, 8.63)	3.9 (3.73, 4.08)
Regional	2.51 (2.19, 2.88)	3.5 (2.63, 4.64)	3.12 (2.25, 4.33)		9.71 (9.4, 10.03)	13.4 (12.5, 14.36)	14.9 (13.88, 16)
Distant	3.56 (2.18, 5.8)	5.53 (3.89, 7.86)	3.4 (2.38, 4.86)		32.17 (29.78, 34.75)	45.25 (42.67, 47.99)	38.74 (36.83, 40.74)
Unknown	1.19 (0.3, 4.75)	3.5 (1.46, 8.41)	1.85 (0.83, 4.11)		7.14 (5.46, 9.35)	12.33 (9.85, 15.44)	7.33 (6.05, 8.88)
Total	2.08 (1.89, 2.29)	4.27 (3.84, 4.75)	1.79 (1.64, 1.94)		6.68 (6.51, 6.85)	11.75 (11.39, 12.12)	3.86 (3.76, 3.97)

BCa, bladder cancer; RC, radical cystectomy; RT, radiotherapy; CT, chemotherapy; SMR, standardized mortality ratio; CI, confidence interval.